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Greenwich
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Beneficiary
Swim Across America is proud to team up with the Alliance for Cancer Gene Therapy (ACGT) for the 6th consecutive year.

Alliance for Cancer Gene Therapy
In 10 years ACGT has funded over
$22 million in grants to the some of the nation’s top investigators in the
field of cell and gene therapy, conducting research at University of
Pennsylvania, Johns Hopkins, Memorial Sloan-Kettering, Duke, Moores UCSD Cancer
Center, Harvard, and Mayo Clinic, among other prestigious medical
institutions. Gene therapy is the process of introducing genetic material,
usually DNA, to fight an acquired or inherited disease. Cell therapy treats
disease by infusing or transplanting whole cells into the patient for the same
purpose.
ACGT supports cell and gene
therapy research for lymphoma, leukemia, ovarian, breast, prostate, pancreatic,
lung, and brain cancers, among others. For the second year Swim Across America
will support Dr. Thomas J. Kipps, MD, Ph.D. at Moores UCSD Cancer Center,
University of California San Diego, La Jolla, CA. Dr. Kipps was awarded a 2010
Investigator Award in Clinical Translation to further test the impact of the
treatment on patients before it moves to a Phase II trial. He was awarded a
2005 Investigator grant for a Phase I trial to test the safety and efficacy of
immune-mediated gene therapy for intractable B Cell Leukemia.
ACGT is leading the way for innovative research using cells and genes as
"medicine." Supporting research projects such as work being done by previous
recipient Dr. Khalid Shah at Harvard/Mass General Hospital, and that of Dr.
Kipps, will lead to more effective and less debilitating treatments for cancer
patients. 100% of the money presented annually to ACGT goes directly to
research – research we all hope will make cancer a manageable disease.
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Message from Dr. Thomas Kipps
I would like to extend my sincere thanks to Swim Across America for this sixth anniversary Greenwich-Stamford Swim. As an ACGT Research Fellow, I appreciate continuing for the second year as the recipient of this Swim to further my development of a new treatment for Chronic Lymphocytic Leukemia (CLL).
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It is the generosity of so many people here today which will expand the work of my laboratory at Moores UCSD Cancer Center in San Diego, CA.
Immunotherapy is considered an especially promising form of gene therapy, in which cells from the patient’s tumor are re-engineered and re-inserted, triggering an immune response previously blocked by the cancer. Chronic lymphocytic leukemia (CLL), the most common form of the disease in adults in Western societies, has generally been incurable. Having worked in the field for more than twenty years, I am encouraged that a more effective treatment for this disease is within reach.
The field has evolved. There is a tremendous amount of new work that’s going on to find the effective targets for gene therapy, and also the delivery vehicles. We’re seeing some very encouraging results right now that are being translated into clinical trials.
Most recently, the combination of gene immunotherapy with chemotherapy is proving to be a safe and more effective treatment for the high-risk CLL patients, with remission rates nine times greater than those in a similar study using chemotherapy alone. ..such an encouraging result.
Dr. Thomas Kipps
Professor of Medicine, Division of Hematology/Oncology Deputy Director of Research,
Moores UCSD Cancer Center, University of California, San Diego, CA
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