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Help Team Charleston-Kiawah raise money for cancer research at Hollings Cancer Center at the Medical University of South Carolina - choose your own activity and goal to virtually travel through every SAA city and go "coast to coast" this summer. Get Registered Today!

WEEKLY COAST TO COAST UPDATE
Week 7 - Updated August 3rd

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Newsletter_416
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FOLLOW AND GET ALL SAA—CHARLESTON-KIAWAH UPDATES
EVENT INFO
ABOUT

Even in these uncertain times, we can continue making waves to fight cancer. As we navigate COVID-19, we've created a special webpage for event updates, helpful information and ways you can continue to support the mission of Swim Across America.

Swim Across America is excited to support cancer research at Hollings Cancer Center at the Medical University of South Carolina with our Charleston - Kiawah Island charity swim.

Join Olympians at this renowned scenic destination in 1.5-mile and 0.5-mile swim options. Our Swim is not a competition, but a fundraising event for everyone, both swimmers and volunteers. Choose a distance to swim or sign up as an event volunteer. We welcome you to the Swim Across America family and our efforts to “Make Waves to Fight Cancer!”

Unfortunately due to COVID-19 we are unable to have a live in-person event this summer. Alternatively, we will be offering a virtual 'Coast to Coast' Challenge as a way for swimmers, volunteers, family and friends to continue to support research at Hollings Cancer Center.

If you have any questions about SAA - Charleston-Kiawah, please contact Brad Johnson.

COAST TO COAST CHALLENGE INFO
ABOUT

Swim Across America - Charleston-Kiawah will be participating in Coast to Coast - a virtual activity tracking and fundraising challenge where participants will work together to travel across America with a mission to support cancer research. Participants can choose their own activity and goals that will support Team SAA - Charleston-Kiawah move across America. Activities can include a walk, bike ride, run, swim or any favorite physical activity in any safe location in your local community. You can even log cancer treatment hours! The virtual route will travel to each Swim Across America open water event city (21 ‘stops’) for a 7,686 mile journey. Tracking will begin June 15th.

CHALLENGE DETAILS
FREQUENTLY ASKED QUESTIONS

Questions about participating in Coast to Coast? All your answers can be found in Frequently Asked Questions.

COAST TO COAST COURSE MAP

The full course map and distances for all legs can be found here.

COAST TO COAST FUNDRAISING TOOLKIT

You can find some new and inspiring fundraising messages crafted for 2020 as well as shareable graphics for Instagram, Facebook and your Participant Center to boost your fundraising for the 'Coast to Coast' challenge here.

MSKCC

SWIM ACROSS AMERICA 2020 COMMEMORATIVE SHIRT

All 2020 SAA - Charleston - Kiawah participants will receive the 2020 commemorative shirt as a thank you for their support and commitment to Swim Across America. This shirt features the slogan "The Mission Doesn't Stop" on the front - a reference to 34 years and counting of impact we've had 'Making Waves To Fight Cancer' with all the SAA cities on back. The tri-blend shirt comes in blue to recognize our frontline heroes in hospitals and research centers in this unprecedented year.

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PARTICIPANT REQUIREMENTS

Registration and Fundraising:

To Join the Coast to Coast Challenge, there is a small personal DONATION of $25 to get you started, and while we will encourage you to fundraise, there is NO Fundraising Minimum to participate. We are all working together as an event to travel coast to coast, but you can still choose to register as an individual or as a part of a fundraising team. Teams can be an inspirational way to honor a loved one and motivate your family and friends to register with you!

 

Already registered for SAA - Charleston-Kiawah? Great! No need to change your registration. You are already eligible to participate in the activity tracking challenge.

 

Note, Online Fundraising Pages on the SAA website are still available, and you can still use Facebook and other Social Media platforms to solicit additional donations. Proceeds from the challenge will support cancer research at Hollings Cancer Center.

OLYMPIAN PARTICIPANTS

PAST OLYMPIAN PARTICIPANTS

JENNY THOMPSON

One of the most decorated Olympians in history: twelve medals, including eight gold medals, in the 1992, 1996, 2000, and 2004 Summer Olympics.

STEVE GREGG

Silver medalist for Team USA in the 200-butterfly at the 1976 Summer Olympics in Montreal. NCAA champion in 1976 at North Carolina State University.

HANNAH ASPDEN

CARLTON BRUNER

KRISTY KOWAL

STEVE LUNDQUIST

ASHLEY WHITNEY

HOW TO FUNDRAISE

If this is your first time participating or if you just need some tips to be a better fundraiser, click here. It will walk you through the participant center and teach you how to email donors, share on social media sites and download the fundraising app.

You may support the swimmer of your choice by making an online donation. Or you may send a check, payable to Swim Across America, to the address below:

Swim Across America
Attn: Brad Johnson
885 Island Park Dr.
Ste C
Charleston, SC 29492

Make sure to include a note with the name of the swimmer you are donating to.

BENEFICIARY

MSKCC

SAA - Charleston-Kiawah funds have supported the Hollings Cancer Center at Medical University of South Carolina since 2019.

2020 GRANT AMOUNT: $50,000

GRANT RECIPIENT: Haizhen (Jen) Wang, Ph.D. (Profile)

PROJECT: CDK6 in T-cell Leukemia Immune Evasion

Project Details: Relapse is the most common cause of treatment failure in acute lymphoblastic leukemia (ALL). It is not clear how leukemia cells escape the immune system to infiltrate and relapse. Upregulation of PD-L1 on cancer cells is one of the important mechanisms to initiate their immune evasion. Recent studies showed that high PD-L1 expression levels are associated with relapse and worse overall survival rates in leukemia. Understanding the regulatory mechanism of PD-L1 expression in leukemia cells will help to develop therapeutic strategies to prevent immune evasion, infiltration and relapse of leukemia. My previous work showed that cyclin-dependent kinase 6 (CDK6) has pro-survival functions in T acute lymphoblastic leukemia (T-ALL) by regulating glycolysis and cellular reactive oxygen species. Recent work by my laboratory found CDK6 facilitates PFKP nuclear translocation to promote leukemia infiltration. Importantly, we found CDK6 dependent phosphomimic PFKP-S679E upregulates PD-L1 expression in T-ALL. This study will elucidate the molecular functions of CDK6 in regulating PD-L1 expression and immune evasion of leukemia cells, and provide fundamental theory about therapeutic effect of CDK6 inhibition on T-ALL relapse. The overarching hypothesis is: CDK6 drives T-ALL immune evasion through the phosphorylation of PFKP and PD-L1 expression.

SPONSORS
Freshfields Village SAA Day Partners

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